ABSTRACT
Objective: To study the hypoglycemic effect and the hypodermic injection irritation of exendin multiple emulsion in tes-ting animals. Methods: Using normal saline and blank multiple emulsion as the blank controls and the marketed exendin injection as the positive control, the hypoglycemic effects of exendin multiple emulsion in healthy mice and mice with gastric administration of 10% glucose solution were studied. Type Ⅱ diabetes rat model was established, and the hypoglycemic effect of exendin multiple emulsion was investigated. The injection of local skin was observed and the slides of injection tissue were studied after HE staining to evaluate the irritation of exendin multiple emulsion. Results: In the healthy mice, the blood glucose reached the lowest point at 90min for ex-endin injection and rose gradually at 120 min, while the blood glucose maintained low levels during the testing period for exendin multi-ple emulsion. After the gastric administration of glucose solution, the blood glucose increased at 60min for exendin injection, while that kept low levels for exendin multiple emulsion. In type Ⅱ diabetes rats, the blood glucose increased gradually after 7-day withdrawal (P<0. 05), while that kept low levels for exendin multiple emulsion. The hypodermic injection of exendin multiple emulsion showed no significant or irreversible irritation to the local skin and tissue. Conclusion: Compared with exendin injection, exendin multiple emul-sion exhibits stable and sustained hypodermic effects with high local use safety.